Aglepristone is a progesterone-receptor antagonist (antiorigestin) indicated for use in canine medicine for control of mesalliance (via termination of pregnancy), luteolysis of ovarian cysts and induction of parturition.
Pharmacologically-induced luteolysis by antiprogestins in early post-implantation pregnancy in dogs results in asynchronous death and resorption of conceptuses.
This drug has also been safely used to minimize risks associated with early elective caesarian section.
Aglepristone is a synthetic steroid with anti-progesterone activity. It works by competitively binding with progesterone receptors and down-regulation of the corpus luteum, leading to luteolysis and cessation of pregnancy.
In vitro studies have demonstrated an affinity three times higher than that of progesterone receptor in the uterus of the bitch. In vivo studies in gestating rats demonstrate that a 10mg/kg dose by subcutaneous injection induced abortion in all treated animals. No anti-glucocorticoid effect was observed in the rat at doses ranging up to 30mg/kg over 4 days by the subcutaneous route.
After therapy with this drug, manual or ultrasonographic examination of the uterus should be performed to ensure uterine evacuation has occurred. In some cases, fetal retention may be an untoward complication. Pregnancy termination can also be confirmed by blood measurement of progesterone (<2 ng/mL).
Recommended dose rate in dogs is 10 mg/kg subcutaneously 24 hrs apart.
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- Virbac Package insert 1p0326-4
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