Carmustine, similar in activity to lomustine, is a mustard gas-related β-chloro-nitrosourea alkylating agent which crosslinks DNA and prevents its replication.
It is usually administered as an adjunct drug in combination with cisplatin, vincristine and prednisolone. A new formulation with carmustine made available as a lipid nanoemulsion has also shown benefit.
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- Lucas SR et al (2013) Pilot clinical study of carmustine associated with a lipid nanoemulsion in combination with vincristine and prednisone for the treatment of canine lymphoma. Vet Comp Oncol Apr 25
- Kitchell BE et al (1994) Intralesional implant for treatment of primary oral malignant melanoma in dogs. J Am Vet Med Assoc 204(2):229-236
- Ricci Lucas SR et al (2004) Carmustine, vincristine, and prednisone in the treatment of canine lymphosarcoma. J Am Anim Hosp Assoc 40(4):292-299