Frohlich's adiposogenital syndrome
Frohlich's adiposogenital syndrome is a rare endocrine disease of dogs associated with hypothalamic disease due to a mass-effect within the sella turcica due to pituitary adenomas, pituitary adenocarcinomas, [[infundibuloma]s or craniopharyngiomas.
A tentative diagnosis can be established by imaging (usually MRI) which may show a pituitary mass, and demonstration of abnormally low GnRH, LH and testosterone blood levels.
A definitive diagnosis requires fine-needle biopsy of pituitary or exploratory craniotomy.
treatment usually requires hypophysectomy. Physically signs usually resolve following surgery.
- Saunders, LZ & Rickard, CG (1952) Craniopharyngioma in a dog with apparent adiposogenital syndrome and diabetes insipidus. Cornell Vet 42(4):490-495