Genetic diseases of dogs

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Listed below are some of the more common genetic diseases in dogs.


Sensory disorders

- Acral mutilation syndrome
- Cataracts
- Collie eye anomaly
- Coloboma
- Cone degeneration
- Congenital stationary night blindness
- Corneal lipid dystrophy
- Deafness
- Dermoid cyst
- Exophthalmos
- Heterochromia - odd-colored eyes
- Microphthalmia
- Multifocal retinopathy
- Primary lens luxation
- Progressive retinal atrophy of Golden Retrievers
- Progressive retinal atrophy -rcd 1a - Sloughi dogs
- Progressive retinal atrophy rcd 3 - Cardigan Welsh Corgi
- Progressive retinal atrophy - Cord 1
- Progressive retinal atrophy - dominant - Bull Mastiff, English Mastiff
- Progressive retinal atrophy -Rcd 1 - Irish Setter
- Progressive retinal atrophy type A - Miniature Schnauzer
- Progressive retinal atrophy - X linked - Samoyed, Siberian Husky
- Progressive rod cone degeneration
- Retinal pigment epithelial dystrophy
- Strabismus - cross-eyed and squints
- Staphyloma

Skin disorders

- Albinism
- Cutaneous asthenia
- Cutaneous xanthoma
- Congenital hypotrichosis
- Epidermolysis bullosa
- Ectodermal dysplasia (X-linked hypohidrotic ectodermal dysplasia)
- Follicular dysplasia
- Hair dysplasia
- Ichthyosiform dermatosis of Cavalier King Charles Spaniels
- Juvenile cellulitis
- Lentigines
- Lethal acrodermatitis
- Natural bob tail
- Piebaldism
- Sebaceous adenitis
- Vitiligo
- Waardenburg syndrome

Hormonal disorders

- Achondroplasia (Dwarfism)
- Congenital hypothyroidism
- Malignant hyperthermia - genetic susceptibility to certain drugs

Neurological disorders

- Acral mutilation syndrome
- Afghan Hound hereditary myelopathy
- Arachnoid cysts
- Atlantoaxial subluxation
- Cerebellar abiotrophy
- Cerebellar hypoplasia
- Cerebellar Purkinje Cell degeneration - Bavarian Mountain Dog
- Cerebellar spongy degeneration - Labrador Retriever, Malinois
- Ceroid lipofuscinosis
- Chiari malformations
- Dandy-Walker syndrome
- Deafness
- Degenerative myelopathy in Pembroke Welsh Corgis and Boxers
- Dermoid cyst
- Dysautonomia
- Encephalomyelopathy
- Episodic falling - Cavalier King Charles Spaniel
- Fibrinoid leukodystrophy
- Globoid cell leukodystrophy
- Hepatocerebellar degeneration
- Hereditary spinal muscular atrophy - Brittany Spaniel
- Hydranencephaly
- Hydrocephalus
- Hyperoxaluria - congenital acute renal failure and secondary neurological signs
- Hypertrophic neuropathy - Tibetan Mastiff
- Hypoganglionosis
- Ivermectin and Multi Drug Sensitivity (MDR 1 gene)
- Leonberger polyneuropathy
- Leucoencephalopathy - Labrador Retriever
- Lissencephaly
- Meningoencephalocele
- Myasthenia gravis
- Narcolepsy
- Neonatal encephalopathy
- Neuroaxonal dystrophy
- Neurovisceral glucocerebrosidosis
- Occipital dysplasia
- Optic nerve hypoplasia
- Osteochondromatosis
- Peripheral nerve hyperexcitability syndrome in Jack Russell terriers
- Polymyositis
- Polyneuropathy
- Porencephaly
- Progressive ataxia
- Pug encephalitis
- Sacrocaudal dysgenesis
- Scotty cramp
- Spina bifida
- Spongiform encephalopathy
- Syringomyelia
- Wobbler syndrome

Cardiovascular disorders

- Arrythmogenic right ventricular cardiomyopathy
- Atrial fibrillation
- Atrial septal defect
- Chemodectoma
- Complement-3 deficiency
- Dilated cardiomyopathy
- Exercise induced collapse - Boykin Spaniel, Chesapeake Bay Retriever, Curly-Coated Retriever
- Factor VII deficiency
- Glanzmann's Thrombasthenia
- Hemophilia A, B
- Hypereosinophilic syndrome
- Mitral valve dysplasia
- Mitral valve endocardiosis
- Patent ductus arteriosus
- Pelger-Huet Anomaly
- Cardiac stenosis
- Subaortic stenosis
- Tetralogy of Fallot
- Thrombopathia
- Tricuspid dysplasia
- Vascular ring anomaly
- Ventricular septal defect
- Von Willebrand's disease

Physical disorders

- Achondroplasia (Dwarfism)
- Atresia ani
- Brachycephalic syndrome
- Bronchoesophageal fistula
- Cataract
- Ciliary dyskinesia
- Cleft palate
- Craniomandibular osteopathy
- Cricopharyngeal achalasia
- Cryptorchidism
- Cutaneous asthenia
- Dermatofibrosis
- Elbow dysplasia
- Elongated soft palate
- Familial juvenile glomerulonephropathy
- Familial protein-losing enteropathy and protein-losing nephropathy - Soft Coated Wheaten Terrier
- Flat chest syndrome
- Fragmented coronoid process
- Gonadal dysgenesis
- Hemimelia
- Hereditary nephropathy - Cocker Spaniel
- Hermaphroditism
- Hernias - perineal hernia, inguinal hernia , umbilical hernia, diaphragmatic hernia, peritoneopericardial diaphragmatic hernia, hiatal hernia
- Hip dysplasia
- Hydrocephalus
- Hypertrophic osteodystrophy
- Hypospadias
- Hypotrichosis
- Legg-Calve-Perthes disease
- Megaoesophagus
- Natural bob tail
- Oculoskeletal dysplasia
- Osteochondrosis (osteochondrosis of the medial humeral condyle)
- Osteogenesis imperfecta
- Panosteitis
- Patellar luxation
- Pectus excavatum
- Pes varus
- Polyarthrodysplasia
- Polycystic kidney disease
- Polydactyly
- Primary ciliary dyskinesia
- Radial agenesis
- Renal cystadenocarcinoma
- Renal dysplasia
- Robertsonian translocation
- Situs inversus totalis
- Tail deformities
- Trisomy-X
- Ununited anconeal process
- Umbilical hernia
- Wobbler syndrome
- X-linked hereditary nephropathy

Myopathies

- Centronuclear myopathy
- Duchenne muscular dystrophy
- Golden Retriever Muscular Dystrophy
- Myasthenia gravis
- Myotubular myopathy
- Myotonia congenita
- Nemaline myopathy
- Primary hyperoxaluria

Enzyme-deficiency disorders and lysosomal storage disease

- Amyloidosis
- Alpha-mannosidosis
- Ceroid lipofuscinosis - neuronal lipid accumulation
- Copper toxicosis
- Cyclic neutropenia (Gray Collie Syndrome)
- Cystinuria
- Fucosidosis
- Galactosialidosis
- Gangliosidosis
- Globoid cell leukodystrophy (Galactosylceramide lipidosis) - neuronal galactocerebrosidase deficiency
- Glycogen storage diseases (glucose-6-phosphatase deficiency)
- Granulation anomaly
- Hereditary osmotic fragility
- Hyperlipidemia - lipoprotein lipase deficiency
- Hyperuricosuria
- L-2-hydroxyglutaric aciduria
- Leukocyte adhesion deficiency
- Methemoglobin reductase deficiency
- Mucopolysaccharidosis
- Nemaline myopathy - familial muscular dystrophy
- Neurovisceral glucocerebrosidosis (Gaucher's disease)
- Niemann-Pick disease
- Phosphofructokinase deficiency
- Pyruvate dehydrogenase phosphatase 1 deficiency
- Pyruvate kinase deficiency

References