Griseofulvin

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Griseofulvin is an antifungal drug used for treatment of dermatophytes such as 'Microsporum spp.

The absorption of griseofulvin is better when administered as a divided dose and with a fatty meal. Side effects are rare in dogs.

Griseofulvin is not recommended for use in puppies less than 12 weeks-of-age, and is highly teratogenic, especially in the first trimester of pregnancy and is therefore contraindicated in pregnant animals.

Bone marrow suppression producing aplastic pancytopenia is a relatively uncommon. These effects can be reversed when treatment is withdrawn.

Griseofulvin does have anti-inflammatory and immunomodulatory properties and is known to suppress delayed hypersensitivity reactions in the skin. These properties can lead to important clinical misinterpretations. Some authors have noted dogs and cats with inflammatory skin disease (for example, bacterial pyoderma) have demonstrated significant clinical improvement while receiving griseofulvin for presumed dermatophytosis[1].

Recommended dose in dogs is 25mg/kg orally once daily for 4 - 6 weeks.

References

  1. Colombo S, Cornegliani, L and Vercelli A (2001) Efficacy of itraconazole as a combination therapy in feline dermatophytosis: preliminary results in nine cases. Veterinary Dermatology 12:347