Because it is a non-specific cyclo-oxygenase (COX-1 and COX-2) inhibitor, it has gastrointestinal, hepatic, coagulation and renal side-effects which limits its long-term use whereas other NSAIDs such as robenacoxib have specific COX-2 selectivity and can be used for long-term manangement of osteoarthritis.
It is regularly given parenterally for peri-operative pain management such as during ovariohysterectomy, used solely or in combination with other analgesics such as tramadol, buprenorphine or codeine.
This drug should not be given with corticosteroids such as prednisolone due to the enhanced risk of pyloric antrum lesions due to the increased gastric acid production effects of both classes of drugs.
Recommended dose rate in dogs is 0.2 - 1.0 mg/kg, given intramuscularly or subcutaneously once daily for less than 5 days.
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