Lithium

From Dog
Jump to: navigation, search

Lithium salts such as lithium carbonate are commonly used in human medicine for a number of schizoaffective disorders and cyclic depression.

In dogs, it is rarely used for this condition but has a number of other applications as it has found to stimulate thrombopoiesis in clinically normal dogs[1].

Lithium has been used in canine medicine for treatment of thrombocytopenia associated with:

The method by which this drug stimulates bone marrow hyperplasia is unknown, but it has been shown to stimulate division of pluripotential stem cells[2].

Recommended dose rate in dogs is 10 - 20 mg/kg orally every 24 hours, in divided doses[3].

During lithium treatment of dogs, serum or plasma lithium concentrations should be measured weekly in order to see if the drug reaches optimum therapeutic levels of 0.5 - 1.8 mmol/L[4].

References

  1. Leclerc A et al (2010) Effects of lithium carbonate on carboplatin-induced thrombocytopenia in dogs. Am J Vet Res 71(5):555-563
  2. Hammond WP & Dale DC. Lithium therapy of canine cyclic hematopoiesis. Blood 55:26–28
  3. Maddux JM & Shaw SE (1983) Possible beneficial effect of lithium therapy in a case of estrogen-induced bone marrow hypoplasia in a dog: A case report. J Am Anim Hosp Assoc 19:242–245
  4. Shabidi NT & Diamond LK (1961) Testosterone-induced remission in aplastic anemia of both acquired and congenital types: Further observations in 24 cases. N Engl J Med 264:953–967