Affected dogs show scales and crusts on the nose pad, which often develop from 6 - 12 months of age. Occasionally they also develop painful fissures on the nose.
Diagnosis is based on clinical symptoms and histological evidence of marked diffuse parakeratotic hyperkeratosis, multiple intracorneal serum lakes and superficial interstitial-to-interface lymphoplasmacytic dermatitis.
A differential diagnosis would include distemper, trauma (constant rubbing against hard surfaces), lupus erythematosus, Malassezia spp and Aspergillus spp dermatitis, localized ringworm, idiopathic seborrhoea, necrolytic migratory erythema, zinc-responsive dermatosis, thallotoxicosis and congenital follicular parakeratosis (mainly Siberian Husky and Rottweiler).
Treatment is usually conservative, with topical applications of propylene glycol in water or white petrolatum often effective at minimizing severity of lesions.
- University of Bern
- Peters J et al (2003) Hereditary nasal parakeratosis in Labrador retrievers: 11 new cases and a retrospective study on the presence of accumulations of serum ('serum lakes') in the epidermis of parakeratotic dermatoses and inflamed nasal plana of dogs. Vet Dermatol 14(4):197-203
- Pagé N et al (2003) Hereditary nasal parakeratosis in Labrador Retrievers. Vet Dermatol 14(2):103-110
- Senter DA et al (2002) Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light-microscopy study of 111 cases (1973-2000). Vet Dermatol 13(1):43-47