Nikkomycin Z is a novel peptide antifungal drug used for treatment of canine fungal infections.
This drugs functions as substrate analogue and inhibits chitin synthase at its catalytic site acts. It has been shown to act synergistically with another chitin synthetase inhibitor caspofungin and the two drugs are sometimes used together in treatment of resistant fungal diseases.
Nikkomycin has shown efficacy against:
Recommended dose rate in dogs is 250 mg in dogs under 15 kg or 500 mg in heavier dogs, given twice daily for 60 days.
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- Ganesan LT et al (2004) In-vitro activity of nikkomycin Z alone and in combination with polyenes, triazoles or echinocandins against Aspergillus fumigatus. Clin Microbiol Infect 10:961–966
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- Verwer PE et al (2012) Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination. Antimicrob Agents Chemother 56(3):1595-1598
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- Shubitz LF et al (2013) Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. Med Mycol Mar 14