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Prazosin is an orally-active α-1-adrenergic antagonist which acts as a sympatholytic drug on vascular smooth muscle.

This drug reduces intraurethral intraluminal pressure and is commonly used in cases of acute urolithiasis and ureterolithiasis<ref>Noguchi Y et al (2008) In vivo study on the effects of alpha1-adrenoceptor antagonists on intraurethral pressure in the prostatic urethra and intraluminal pressure in the vas deferens in male dogs. Eur J Pharmacol 580(1-2):256-261<ref>.

Recommended dose rate in dogs is 20-50 μg/kg.