Difference between revisions of "Ronidazole"

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Ronidazole is an anthelmintic drug used for various internal [[parasites]].
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Ronidazole is a [[benzimidazole]] [[parasites|anthelmintic]] drug used for various internal [[parasites]].
  
Trichomonads such as ''[[Giardia spp]]'' and ''[[Cryptosporidium spp]]'' lack the mitochondria needed for aerobic metabolism. Instead, pyruvate is generated by glycolysis and fermented in reductive organelles called hydrogenosomes. This reductive metabolic pathway serves as the basis for the susceptibility of trichomonads to 5-nitroimidazole antibiotics, such as ronidazole.
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In canine medicine, it is primarily used to treat ''[[Giardia spp]]''<ref>Fiechter R ''et al'' (2012) Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel. ''Vet Parasitol'' '''187(1-2)''':93-98</ref> and ''[[Cryptosporidium spp]]''.
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Side-effects such as [[gastroenteritis]] and neurological signs may be evident at doses which exceed recommended levels.
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Recommended dose rate in dogs is 30 - 50mg/kg orally twice daily for 7 days.
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==References==
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<References/>

Latest revision as of 23:50, 26 March 2013

Ronidazole is a benzimidazole anthelmintic drug used for various internal parasites.

In canine medicine, it is primarily used to treat Giardia spp[1] and Cryptosporidium spp.

Side-effects such as gastroenteritis and neurological signs may be evident at doses which exceed recommended levels.

Recommended dose rate in dogs is 30 - 50mg/kg orally twice daily for 7 days.

References

  1. Fiechter R et al (2012) Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel. Vet Parasitol 187(1-2):93-98