Tolfenamic acid

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Tolfedine (Tolfenamic acid) belongs to the class of NSAIDs and is recommended for use as an analgesic in post-operative pain and fever, and treatment of various neoplastic conditions such as interstitial cell tumor and melanomas.

Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) belongs to the fenamate group and is a potent inhibitor of cyclo-oxygenase enzyme, thus inhibiting the synthesis of important inflammatory mediators such as thromboxane (Tx)B2 and prostaglandin (PG)E2. It acts not only by inhibiting prostaglandin synthesis, but it also has a direct antagonistic action on its receptors.

Tolfedine shows marked analgesic and antipyretic properties comparable to meloxicam[1]. It is well absorbed by the oral route and shows a complete bioavailability even in the presence of food.

After oral administration, efficient blood levels are rapidly reached (CMAX is reached within 1 to 2 hours in fasted animals, or 2 to 4 hours when administered with the meal) and maintained sufficiently high to exert a satisfactory anti-inflammatory action for at least 24 to 36 hours.

Tolfedine should be discontinued with dogs that show signs of anorexia, diarrhoea or vomiting. Regular blood testing of renal function is highly recommended.

Recommended dose in dogs is 4 mg/kg given IM, SQ or orally every 24 hours up to 5 days, 3 out of 7 days for long term therapy.

References

  1. Hugonnard M et al (2004) Attitudes and concerns of French veterinarians towards pain and analgesia in dogs and cats. Vet Anaesth Analg 31(3):154-163