From Cat

Demeclocycline is a tetracycline antibiotic indicated for Lyme disease, acne and bronchitis. Due to its effect on lowering intraocular pressure, it may be useful in feline glaucoma[1].

Similar to vasopressin in its effect on inducing diabetes insipidus[2], demeclocyline is also used in cats for the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone when fluid restriction alone has been ineffective.

Recommended dose in cats is 3 - 12 mg/kg given oprally every 6 - 12 hours.


  1. Wallace I et al (1989) The ocular hypotensive effects of demeclocycline, tetracycline and other tetracycline derivatives. Invest Ophthalmol Vis Sci 30(7):1594-1598
  2. Cameron K & Gallagher A (2010) Syndrome of inappropriate antidiuretic hormone secretion in a cat. J Am Anim Hosp Assoc 46(6):425-432