Ivermectin is a macrocyclic lactone derived from fermentation of the bacteria Streptomyces avermitilis. Other avermectins used on cats include selamectin.
Although shown to be effective in off-label use against Dirofilaria immitis and other filariids, Bot flies (Cuterebra spp and Cochliomyia spp), fleas (Ctenocephalides felis, Ctenocephalides canis, Echidnophaga gallinacea, Pulex irritans) and lice (Felicola subrostratus, Heterodoxus spiniger), ivermectin has poor efficacy against some dermal mites such as Demodex spp. Some reports shown efficacy against Sarcoptes spp.
Ivermectin toxicity has been reported as a common occurrence in cats.
The recommended dose for injectable ivermectin is 0.1cc/kg SQ stat, or once weekly for ectoparasites. Oral dose is 24 µg/kg once monthly.
- Chittrakarn S et al (2009) Pharmacokinetics of ivermectin in cats receiving a single subcutaneous dose. Res Vet Sci 86(3):503-507
- Chansiri G et al (2005) The efficacy of a single-oral-dose administration of ivermectin and diethylcarbamazine on the treatment of feline Brugia malayi. Southeast Asian J Trop Med Public Health 36(5):1105-1109
- Fisher MA & Shanks DJ (2008) A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats. Acta Vet Scand 50:46
- Malik R et al (2006) Crusted scabies (sarcoptic mange) in four cats due to Sarcoptes scabiei infestation. J Feline Med Surg 8(5):327-339