Mucopolysaccharidosis

From Cat
MPS VI in a British kitten, newborn. Photo courtesy of Dr Jim Euclid
Same kitten as above, showing cleft palate
Same kitten as above, showing facial dysmorphism

Mucopolysaccharidosis (MPS) is a genetic disease of cats that has a number of variants:

These diseases are a storage disease which results from excessive accumulation of mucopolysaccharides in lysosomes within cells throughout the cat's body. Mucopolysaccharidoses (MPS) are lysosomal storage disorders, each caused by the deficiency of a lysosomal hydrolase needed for the degradation of mucopolysaccharide (glycosaminoglycan).

The form of MPS affects the clinical syndrome seen, although clinically it is hard to distinguish the different forms and required DNA testing to ascertain the type.