From Cat

Vasopressin (Antidiuretic hormone - ADH; Desmopressin) is a critical hormone in the regulation of water balance and appetite[1], effected upon the renal tubules. Its function is similar to angiotensin upon water retention.

Vasopressin is secreted from the posterior pituitary gland in response to reductions in plasma volume, in response to increases in the plasma osmolality, and in response to cholecystokinin secreted by the small intestine. It results in water and sodium resorption. In higher doses, it also causes hyponatremia and vasocontriction, resulting in hypertension[2] and has been used in the treatment of syndrome of inappropriate antidiuretic hormone .

Depression in endogenous levels of vasopressin result in diabetes insipidus in cats, and administration of vasopressin can help remedy this disease in some feline patients[3].


  1. Vaguin YE et al (2005) Cycloheximide and lysylvasopressin alter the degree of freedom of cortical neurons involved in food-procuring behavior of cats. Dokl Biol Sci 405:424-426
  2. Cameron K & Gallagher A (2010) Syndrome of inappropriate antidiuretic hormone secretion in a cat. J Am Anim Hosp Assoc 46(6):425-432
  3. Campbell FE & Bredhauer B (2008) Trauma-induced central diabetes insipidus in a cat. Aust Vet J 86(3):102-105