Bovine achondrogenesis ('bulldog calf') is a rare recessive lethal genetic disease of cattle worldwide.
This disease is a genetic mutation characterized by hypertrophic and degenerative chondrocytes normally found in the growth plate. The genetic mutation causes achondrogenesis, hypochondrogenesis and spondyloepiphyseal dysplasia.
Affected calves may be stillborn or die shortly after birth with characteristic shortened bulldog-like limbs.
- Horton WA et al (1987) Bovine achondrogenesis: evidence for defective chondrocyte differentiation. Bone 8(3):191-197
- Spranger J (1988) Bone dysplasia 'families'. Pathol Immunopathol Res 7(1-2):76-80