From Cow
Achondrogenesis in a stillborn Hereford calf

Bovine achondrogenesis ('bulldog calf') is a rare recessive lethal genetic disease of cattle worldwide.

This disease is a genetic mutation characterized by hypertrophic and degenerative chondrocytes normally found in the growth plate[1]. The genetic mutation causes achondrogenesis, hypochondrogenesis and spondyloepiphyseal dysplasia[2].

Affected calves may be stillborn or die shortly after birth with characteristic shortened bulldog-like limbs.


  1. Horton WA et al (1987) Bovine achondrogenesis: evidence for defective chondrocyte differentiation. Bone 8(3):191-197
  2. Spranger J (1988) Bone dysplasia 'families'. Pathol Immunopathol Res 7(1-2):76-80