Anterior segment dysgenesis

From Cow

Bovine anterior segment dysgenesis is a rare autosomal recessive congenital eye disease of calves worldwide[1].

This disease is characterised by calves born with visual defects[2]. This disease may be unilateral or bilateral[3]. Glaucoma has been reported in association with this disease.

Affected calves are often culled due to worsening visual loss.

Other congenital diseases such as microphthalmos, microcoria, microcornea, microlentia, cataracts, retinal dysplasia, retinal detachment, acorea and proliferation of the anterior neuroectoderm[4].


  1. Abbasi AR et al (2009) A mutation of the WFDC1 gene is responsible for multiple ocular defects in cattle. Genomics 94(1):55-62
  2. Kaswan RL et al (1987) Multiple hereditary ocular anomalies in a herd of cattle. J Am Vet Med Assoc 191(1):97-99
  3. Hurley S (2008) Blind but healthy calves. Vet Rec 163(19):579
  4. Rupp GP & Knight AP (1984) Congenital ocular defects in a crossbred beef herd. J Am Vet Med Assoc 184(9):1149-1150