Benzimidazoles

From Cow

Benzimidazoles are a group of antiinfective anthelmintics used for various diseases in cattle such as roundworms, lungworm and infections with Giardia spp, Tritrichomonas spp and Trypanosoma spp infections.

Once the drug enters the parasite it becomes activated by the reduction of the nitro group and binds covalently to DNA molecules, resulting in irreversible helical damage and death of the organism[1]. Drug resistance in cattle strongyles to anthelmintics is rarely described

Most benzimidazoles are also effective anthelmintics, active against most nematodes and resistance to this antihelmintic is less frequent than with macrocyclic lactones such as ivermectin[2].

Drugs in this class include:

References

  1. Payne PA & Artzer M (2009) The biology and control of Giardia spp and Tritrichomonas foetus. Vet Clin North Am Small Anim Pract 39:993–1007
  2. Rendell DK (2010) Anthelmintic resistance in cattle nematodes on 13 south-west Victorian properties. Aust Vet J 88(12):504-509