From Cow

Ceftiofur is a third-generation cephalosporin.

It is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported[1].

Ceftiofur is indicated for treatment of Bovine respiratory disease and acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.

Treatment should be repeated at 24 hour intervals for a total of three consecutive days. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments. May be used in lactating dairy cattle.

Recommended dose is 2.2 mg/kg body weight.


  1. Hornish RE & Kotarski SF (2002) Cephalosporins in veterinary medicine - ceftiofur use in food animals. Curr Top Med Chem 2(7):717-731