DUMPS

From Cow
Collections of bovine-mummified fetuses used for DUMPS analysis[1].

Bovine uridine monophosphate synthase deficiency (DUMPS) is a rare metabolic genetic disorder of cattle worldwide[2].

The disease has been reported in Holstein, Holstein-Friesian and Wagyu breeds[3].

Similar to citrullinemia, factor XI deficiency and leukocyte adhesion deficiency, this genetic disease is autosomal recessive and breed specific[4].

DUMPS is caused by a mutation of uridine monophosphate synthetase (UMPS) protein, resulting in pyrimidine deficiencies. Clinical signs are often noted during pregnancy, when abortion occurs due to affected calves dying in utero during the first trimester. Affected carrier cows are usually subclinically affected despite having diminished UMPS activity.

Diagnosis is based on PCR analysis (polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)) of suspect cases and for screening of potential sires[5].

A differential diagnosis would include other causes of abortion and neurological signs such as bovine epizootic abortion, listeriosis, epizootic encephalomyelitis, sporadic bovine encephalomyelitis, Aino virus, rabies and toxoplasmosis.

Treatment is usually unsuccessful. The only way to avoid the economic losses is early detection of DUMPS carriers[6].

As artificial insemination is widely used in dairy cattle breeding, carriers of citrullinemia are likely present within the population of breeding sires. It is recommended to screen breeding sires for these defective genes in order to avoid an unwanted spread within the population[7].

References

  1. Ghanem ME et al (2006) Deficiency of uridine monophosphate synthase (DUMPS) and X-chromosome deletion in fetal mummification in cattle. Anim Reprod Sci 91(1-2):45-54
  2. Windsor P & Agerholm J (2009) Inherited diseases of Australian Holstein-Friesian cattle. Aust Vet J 87(5):193-199
  3. Ohba Y et al (2007) Japanese black cattle with orotic aciduria detected by gas-chromatography/mass-spectrometry. J Vet Med Sci 69(3):313-316
  4. Sun DX et al (2011) Short communication: Distribution of recessive genetic defect carriers in Chinese Holstein. J Dairy Sci 94(11):5695-5698
  5. Poli MA et al (1996) PCR screening for carriers of bovine leukocyte adhesion deficiency (BLAD) and uridine monophosphate synthase (DUMPS) in Argentine Holstein cattle. Zentralbl Veterinarmed A 43(3):163-168
  6. Kaminski S et al (2005) No incidence of DUMPS carriers in Polish dairy cattle. J Appl Genet 46(4):395-397
  7. Meydan H et al(2010) Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, complex vertebral malformation, bovine citrullinaemia, and factor XI deficiency in Holstein cows reared in Turkey. Acta Vet Scand 52:56