Danofloxacin

From Cow
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Danofloxacin is a synthetic fluoroquinolone with broad spectrum antibacterial activity. It is used in the treatment of bovine respiratory disease and pneumonia in cattle[1].

The drug is well absorbed when administered parenterally or orally. Both the parent drug as the major component and desmethyldanofloxacin in very small quantities are excreted in milk, feces and urine[2].

Recommended dose is 1.25 mg/kg body weight intramuscularly for 5 successive days.

References

  1. Katsuda K et al (2009) Antimicrobial resistance and genetic characterization of fluoroquinolone-resistant Mannheimia haemolytica isolates from cattle with bovine pneumonia. Vet Microbiol 139(1-2):74-79
  2. Mestorino N et al (2009) Concentrations of danofloxacin 18% solution in plasma, milk and tissues after subcutaneous injection in dairy cows. Anal Chim Acta 637(1-2):33-39