Heterochromia iridis

From Cow

Heterochromia iridis is a rare autosomal recessive congenital eye disease of calves worldwide[1].

This disease is characterised by calves born with different colored irises[2].

In cattle, heterochromia iridis is asymptomatic and calves have normal visual acuity.

Other congenital diseases such as microphthalmos, microcoria, microcornea, microlentia, cataracts, retinal dysplasia, retinal detachment, anterior segment dysgenesis, acorea and proliferation of the anterior neuroectoderm[3].


  1. Abbasi AR et al (2009) A mutation of the WFDC1 gene is responsible for multiple ocular defects in cattle. Genomics 94(1):55-62
  2. Kaswan RL et al (1987) Multiple hereditary ocular anomalies in a herd of cattle. J Am Vet Med Assoc 191(1):97-99
  3. Rupp GP & Knight AP (1984) Congenital ocular defects in a crossbred beef herd. J Am Vet Med Assoc 184(9):1149-1150