Hyperlipidemia

From Cow

Hyperlipidemia is a rare genetic disease of calves characterised by elevated circulating lipids, unrelated to dietary source[1].

In one cases, the affected calf was clinically normal, but with this disease, acute onset lipid aqueous of the eye may occur.

Haematological tests in the affected calf revealed extremely high concentrations of triglycerides, cholesterol and phospholipids, in particular in chylomicrons (CM) and very low-density lipoprotein (VLDL) fraction. Haptoglobin and serum Amyloid A were detected in the serum as well, suggesting that the two apolipoproteins may be involved in the pathogenesis of calf hyperlipidemia.

Diagnosis is based on haematological findings and exclusion of other diseases such as hyperlipidemia associated with abdominal fat necrosis (lipomatosis).

No treatment has been recorded for this disease in cattle.

References

  1. Yamamot M et al (2000) Increased serum concentration of apolipoprotein C-III and its greater distribution to chylomicrons than to the high-density lipoprotein fraction in a calf with hyperlipidemia. J Vet Med Sci 62(10):1033-1039