In cattle, two inherited forms of ichthyosis have been reported, both caused by single autosomal recessive genes. The most severe and lethal form (fetal ichthyosis) was described in Norwegian Red, Friesian, and Brown Swiss calves. Congenital ichthyosis is less severe, and lesions are more localized.
Histopathological feature include excess compact orthokeratotic hyperkeratosis involving surface of the epidermis and follicular epithelia. Harlequin ichthyosis is a more severe form, where newborn calves have ichthyosis as well as small malformed ears, ectropion, eclabium and nasal deformities.
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