Excretion from bovine blood is very slow. Over the first 10 days, only 53% of the dose is recovered in excreta, with 38% in the faeces and 15% in the urine. Residues in tissues are very persistent, particularly in liver where mean residues of 2200µg-equivalents/kg is found 90 days after treatment.
The signs of toxicity in cattle are generally consistent with the anticholinesterase activity of imidocarb and included lethargy, salivation, lachrymation, muscle fasciculation, ataxia, tremors, and convulsions. Congestion of the lung and kidneys and mottling of the liver are frequent post-mortem findings.
Recommended dose for cattle is 2.1 mg/kg bodyweight.
- Ferguson, E (1996) (14C)-Imidocarb: Absorption, distribution, metabolism and excretion in cattle following a single subcutaneous injection of Imizol. Unpublished report No. S8107-001-R from Corning Hazleton (Europe). Submitted to WHO by Mallinckrodt, Harefield, Uxbridge, Middlesex, United Kingdom
- Coldham NG et al (1995) Imidocarb residues in edible bovine tissues and in vitro assessment of imidocarb metabolism and cytotoxicity. Drug Metab Dispos 23(4):501-505