Lyssavirus

From Cow
Electron microscopic view of Lyssavirus

Lyssaviruses are a group of single-stranded RNA viruses which cause rabies in cattle.

The single-stranded RNA molecule that encodes five viral proteins: polymerase L, matrix protein M, phosphoprotein P, nucleoprotein N, and glycoprotein G, which form a separate monophyletic lineage consisting of sub-lineages A and B[1]. Genetic markers on the Lyssavirus indicates a possible variation between geographic regions, although the biologically active regions are conserved[2].

In cattle, Lyssaviral antigens are most prominent in the brainstem, followed by the cerebellum[3].

References

  1. Hirano S et al (2010) Analysis of Chinese rabies virus isolates from 2003-2007 based on P and M protein genes. Acta Virol 54(2):91-98
  2. Macedo CI et al (2010) Genetic characterization of rabies virus isolated from bovines and equines between 2007 and 2008, in the States of São Paulo and Minas Gerais. Rev Soc Bras Med Trop 43(2):116-120
  3. Stein LT et al (2010) Immunohistochemical study of rabies virus within the central nervous system of domestic and wildlife species. Vet Pathol 47(4):630-633