Marbofloxacin

From Cow
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Marbofloxacin is a fluoroquinolone antimicrobial drug effective against Gram-negative and some Gram-positive bacteria.

Marbofloxacin has been shown to be effective against:

This drug is indicated for use in cattle for diseases such as:

When used for mastitis, the drug penetrates into milk rapidly and extensively with milk marbofloxacin concentrations exceeding those in serum two hours after administration. Milk drug concentrations equal to or greater than the minimal inhibitory concentrations for the majority of gram-negative udder pathogens are maintained for approximately 12 hours after IV and IM injections at dose rates of 2 - 4 mg/kg. The drug is not detected in milk 24 hours after treatment.

This drug can be safely co-administered with NSAIDs such as tolfedine[3].

Recommended dose in cattle is 2 - 4 mg/kg bodyweight once daily.

References

  1. Spreng M et al (1995) Antibacterial activity of marbofloxacin. A new fluoroquinolone for veterinary use against canine and feline isolates. J Vet Pharmacol Ther 18(4):284-289
  2. Farca AM et al(2007) In vitro antimicrobial activity of marbofloxacin and enrofloxacin against bacterial strains isolated from companion animals. Schweiz Arch Tierheilkd 149(6):265-271
  3. Sidhu PK et al(2012) Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves. J Vet Pharmacol Ther 34(4):376-387