Oxfendazole

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Oxfendazole is a benzimidazole anthelmintic manufactured for use in control of intestinal parasites in cattle including roundworms, Giardia spp and Tritrichomonas spp[1]. Oxfendazole is the sulphoxide metabolite of fenbendazole.

Oxfendazole reaches peak blood levels more slowly than older benzimidazoles, thereby maintaining effective concentrations for a longer time in both the serum and the intestinal tract. After oral administration, only half of the dose is eliminated after 6 days, indicating a fairly high degree of sequestration, probably within the gastrointestinal tract[2].

Oxfendazole is effective against nematodes (roundworms, hookworms and whipworms), cestodes but not trematodes.

Recommended dose rate is 5 - 10 mg/kg bodyweight[3].

References

  1. Edmonds MD et al (2010) Anthelmintic resistance of Ostertagia ostertagi and Cooperia oncophora to macrocyclic lactones in cattle from the western United States. Vet Parasitol 170(3-4):224-229
  2. Rendell DK (2010) Anthelmintic resistance in cattle nematodes on 13 south-west Victorian properties. Aust Vet J 88(12):504-509
  3. Yazwinski TA et al (2009) Fecal egg count reduction and control trial determinations of anthelmintic efficacies for several parasiticides utilizing a single set of naturally infected calves. Vet Parasitol 164(2-4):232-241