Polymixin B is an antimicrobial drug effective against Gram-negative bacterial diseases.
Polymixin B is a cyclic cationic polypeptide antibiotic that binds to the lipid A subunit of endotoxin molecules with high affinity, preventing the interaction of endotoxin with humoral and cellular receptors and the resultant activation of inflammatory pathways. This drug inhibits activation of nuclear factor kappa B (NK-kB) by neutralising LPS. Kappa B is one of the primary cytokine transcription regulators during Gram-negative sepsis.
Treatment with polymixin B in high-dose intravenous trials has shown its efficacy in reducing endotoxaemia and increasing survival rates in cattle.
- Shimokawa K et al (2012) Adsorption of various antimicrobial agents to endotoxin removal polymyxin-B immobilized fiber (Toraymyxin®). Colloids Surf B Biointerfaces 90:58-61
- Brown, MA & Jones, WK (2004) NF-kappa B action in sepsis: the innate immune system and the heart. Front Biosci 9:1201-1217
- Alemu S & Zewde BM (2012) Prevalence and antimicrobial resistance profiles of Salmonella enterica serovars isolated from slaughtered cattle in Bahir Dar, Ethiopia. Trop Anim Health Prod 44(3):595-600