From Cow

Sepsis is defined as a systemic and often overwhelming 'infectious inflammatory response to infection by bacterial diseases in cattle. Formerly known as septicaemia, sepsis can often lead to DIC and has a high morbidity and mortality in cattle. Sepsis can thus be distinguished from noninfectious systemic inflammatory response syndrome (SIRS).

Sepsis may be a consequent of acute infection. In cattle, bacteria associated with sepsis include Escherichia coli, Pseudomonas spp, and gram-positive bacteria (Streptococcus spp and Staphylococcus spp).

Sepsis can also occur as a result of acute severe trauma such as motor vehicle accidents, burns, etc. Clinically, affected cattle presents with lethargy, hyperthermia (early) or hypothermia (in end-stage sepsis).

During Gram-negative sepsis, endotoxin or lipopolysaccharide (LPS), the glycolipid component of bacterial cell wall is released into the circulation, resulting in a systemic inflammatory response that can lead to multi-organ dysfunction and death.

Treatment of sepsis in cattle involves aggressive use of Intravenous fluid therapy, antimicrobial therapy and anti-endotoxin drugs such as NSAIDs and Polymixin B.