Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) belongs to the fenamate group and is a potent inhibitor of cyclo-oxygenase enzyme, thus inhibiting the synthesis of important inflammatory mediators such as thromboxane (Tx)B2 and prostaglandin (PG)E2. It acts not only by inhibiting prostaglandin synthesis, but it also has a direct antagonistic action on its receptors.
Tolfedine shows marked analgesic and antipyretic properties comparable to meloxicam. It is well absorbed by the oral route and shows a complete bioavailability even in the presence of food.
After oral administration, efficient blood levels are rapidly reached (CMAX is reached within 1 to 2 hours in fasted animals, or 2 to 4 hours when administered with the meal) and maintained sufficiently high to exert a satisfactory anti-inflammatory action for at least 24 to 36 hours.
Recommended dose in cattle is 4 mg/kg given IM, SQ or orally.