Toxic epidermal necrolysis
Clinical signs in affected cattle are characterised by full-thickness epidermal exfoliation.
Diagnosis is one of exclusion after ruling out underlying disease or drug administration. Histopatholigcal analysis of affected tissue shows spongiosis of the epidermis and extensive apoptotic loss of keratinocytes.
Secondary bacterial infections are common.
Treatment is usually symptomatic, with topical applications of broad-spectrum antibiotic and antiinflammatory emollients. Systemic and/or topical corticosteroids and antibiotics such as Ceftiofur may minimise the severity in valuable cattle.
- Yeruham I et al (1999) Case report: idiopathic toxic epidermal necrolysis in a one-week old calf. Berl Munch Tierarztl Wochenschr 112(5):172-173
- Senturk S et al (2012) Toxic epidermal necrolysis associated with Mycoplasma bovis in calves. Vet Rec 170(22):566
- White BJ et al (2012) Clinical, behavioral, and pulmonary changes in calves following inoculation with Mycoplasma bovis. Am J Vet Res 73(4):490-497