Tylosin is a broad-spectrum coccidiostat and bacteriostat which is commercially available as a feed additive and injectable antimicrobial. It is used widely in beef and dairy cattle. It has a broad spectrum of activity against gram positive organisms and a limited range of gram negative organisms.
Tylosin is recommended for intramuscular injection only in beef cattle, nonlactating dairy cattle for use in the treatment of bovine respiratory disease, foot rot, calf diphtheria and contagious bovine pleuropneumonia. resistance has been reported and should be monitored in clinical cases.
Recommended dose in cattle is 10 mg/kg intramuscularly twice daily for 6 injections (using the 200 mg/mL preparation).
Side effects consisting of edema of the rectal mucosa, anal protrusion, diarrhea, erythema and pruritus have been observed in some hogs following the use of tylosin. Discontinuation of treatment effected an uneventful recovery. Discontinue use in cattle 21 days before slaughter.
- Rérat M et al (2012) Bovine respiratory disease: efficacy of different prophylactic treatments in veal calves and antimicrobial resistance of isolated Pasteurellaceae. Prev Vet Med 103(4):265-273