Osteogenesis imperfecta

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Osteogenesis imperfecta is an autosomal recessive multifactorial genetic disease of cattle worldwide.

Osteogenesis imperfecta is characterized by a generalized by extreme fragility of bones and joint laxity due to type I collagen dysplasia.

Clinically affected calves often present with spontaneously fractures.

Diagnosis is based on presenting clinical signs, radiographic evidence of slender, thin-cortices of long bones and immunohistochemical identification of the disease using PCR and western blot techniques.