Acemannan is a D-isomer mucopolysaccharide found in aloe vera leaves.
This compound has been known to have immunostimulant, antiviral, antineoplastic and gastrointestinal properties.
In dogs, it has been used for treatment of chronic viral infections and cancers such as osteosarcoma, melanoma, lymphosarcoma and fibrosarcomas in combination with surgery and radiation therapy.
Recommended dose rate in dogs is 1 - 2 mg/kg given intralesionally, intraperitoneally or subcutaneously once a week.
- Kruth SA et al (1998) Biological response modifiers: interferons, interleukins, recombinant products, liposomal products. Vet Clin North Am Small Anim Pract 28(2):269-295
- King GK et al (1995) The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas. J Am Anim Hosp Assoc 31(5):439-447
- Fogleman RW et al (1992) Subchronic oral administration of acemannan in the rat and dog. Vet Hum Toxicol 34(2):144-147
- Fogleman RW et al (1992) Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. Vet Hum Toxicol 34(3):201-205