Acemannan

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Acemannan.jpg

Acemannan is a D-isomer mucopolysaccharide found in aloe vera leaves.

This compound has been known to have immunostimulant, antiviral, antineoplastic and gastrointestinal properties[1].

In dogs, it has been used for treatment of chronic viral infections and cancers such as osteosarcoma, melanoma, lymphosarcoma and fibrosarcomas in combination with surgery and radiation therapy[2][3].

Recommended dose rate in dogs is 1 - 2 mg/kg given intralesionally, intraperitoneally or subcutaneously once a week[4].

References

  1. Kruth SA et al (1998) Biological response modifiers: interferons, interleukins, recombinant products, liposomal products. Vet Clin North Am Small Anim Pract 28(2):269-295
  2. King GK et al (1995) The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas. J Am Anim Hosp Assoc 31(5):439-447
  3. Fogleman RW et al (1992) Subchronic oral administration of acemannan in the rat and dog. Vet Hum Toxicol 34(2):144-147
  4. Fogleman RW et al (1992) Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. Vet Hum Toxicol 34(3):201-205