Acetazolamide

From Dog
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Acetazolamide is a carbonic anhydrase inhibitor which acts as a diuretic in dogs[1].

This drug acts by inhibiting NaHCO3 and NaCl reabsorption in the ascending loop of Henle[2].

This drug is indicated in acute renal injury associated with oliguria or anuria, or in cases of pulmonary hypertension[3], generalized systemic or peripheral edema.

This drug has also been used for treatment of caval syndrome[4] and cerebral edema associated with syringomyelia and hydrocephalus[5].

Recommended dose rate in dogs is 5 - 10 mg/kg given orally every 8 - 12hrs.

References

  1. Gougoux A et al (1987) Effect of acetazolamide on renal metabolism and ammoniagenesis in the dog. Kidney Int 31(6):1279-1290
  2. Kiil F & Sejersted OM (2003) Analysis of energy metabolism and mechanism of loop diuretics in the thick ascending limb of Henle's loop in dog kidneys. Acta Physiol Scand 178(1):73-82
  3. Höhne C et al (2004) Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs. J Appl Physiol 97(2):515-521
  4. Levy M (1990) Comparative effects of diuretics and atrial peptide in chronic caval dogs. Am J Physiol 258(4):F768-F774
  5. Itoh T et al (1996) Syringomyelia and hydrocephalus in a dog. J Am Vet Med Assoc 209(5):934-936