Acitretin

From Dog

Acitretin is a second-generation retinoid that is a metabolite of etretinate, and a safer product for use in canine skin diseases[1].

Acitretin seems to act rather as a substrate in dermatological disease repair than an enzymatic inducer[2].

This retinoid has been used successfully in spiculosis.

Recommended dose in dogs is 0.5 - 2.0 mg/kg every 24 hrs orally.

References

  1. Thongnopnua P et al (1989) The pharmacokinetics of etretinate and its metabolites in the dog. Drug Metab Dispos 17(5):473-480
  2. Laugier JP et al (1994) Acitretin biotransformation into etretinate: role of ethanol on in vitro hepatic metabolism. Dermatology 188(2):122-125