Albendazole

From Dog
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Albendazole is a benzimidazole anthelmintic used for parasite control in dogs.

This drug has similar pharmacokinetics to other benzimidazoles such as fenbendazole and oxfendazole[1].

Albendazole appears less effective at clearing Mesocestoides spp infections with compared to fenbendazole[2], but more effective than milbemycin and other benzimidazoles at clearing Trichinella spp[3].

It has proven efficacy against the metacestode stages of Echinococcus multilocularis[4][5][6], various lungworm species, Giardia spp[7] and Tritrichomonas spp.

High doses have shown to cause bone marrow dysplasia[8], with subsequent anemia, leukopenia and thrombocytopenia[9].

Albendazole induced toxicosis appears to be dose related and reversible[10], and withdrawal should be instituted in any dog with untoward symptoms, and supportive therapy including blood transfusion, nandrolone and lithium carbonate supplements considered.

Recommended dose in dogs is 25 - 50 mg/kg orally twice daily for 2 - 5 days[11][12].

References

  1. Gokbulut C et al (2007) Comparative plasma disposition of fenbendazole, oxfendazole and albendazole in dogs. Vet Parasitol 148(3-4):279-287
  2. Crosbie PR et al (1998) Diagnostic procedures and treatment of eleven dogs with peritoneal infections caused by Mesocestoides spp. J Am Vet Med Assoc 213(11):1578-1583
  3. Bowman DD et al (1993) Treatment of experimentally induced trichinosis in dogs and cats. Am J Vet Res 54(8):1303-1305
  4. Haller M et al (1998) Surgical and chemotherapeutic treatment of alveolar echinococcosis in a dog. J Am Anim Hosp Assoc 34(4):309-314
  5. Sharif MA et al (2009) Primary perisplenic hydatid cyst. J Coll Physicians Surg Pak 19(6):380-382
  6. van Riel A et al (2007) A dog with alveolar echinococcosis: the larval stage of the fox tapeworm. Tijdschr Diergeneeskd 132(21):828-831
  7. Chon SK & Kim NS (2005) Evaluation of silymarin in the treatment on asymptomatic Giardia infections in dogs. Parasitol Res 97(6):445-451
  8. Stokol T et al (1997) Development of bone marrow toxicosis after albendazole administration in a dog and cat. J Am Vet Med Assoc 210(12):1753-1756
  9. Meyer EK (1998) Adverse events associated with albendazole and other products used for treatment of giardiasis in dogs. J Am Vet Med Assoc 213(1):44-46
  10. Stokol T et al (1997) Development of bone marrow toxicosis after albendazole administration in a dog and cat. J Am Vet Med Assoc 210(12):1753-1756
  11. Dib A et al (2011) Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs. J Vet Pharmacol Ther 34(2):136-141
  12. Barr SC et al (1993) Efficacy of albendazole against giardiasis in dogs. Am J Vet Res 54(6):926-928