This disease is caused by malfunction of the enamel proteins ameloblastin, enamelin, tuftelin and amelogenin.
Clinically affected dogs present with discolored teeth.
Diagnosis is based on radiographic evidence of imperfect enamel formation and histological examination of teeth, which usually show enamel containing large amounts of organic matrix and poorly mineralized enamel.
There is no treatment for this condition, but symptoms are usually mild in most dogs. In some patients, this condition may lead to pulpitis and death of the affected tooth or teeth. Dentin sensitivity is a concern, especially if multiple teeth are affected.
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- Gruenbaum-Cohen Y et al (2009) Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis. J Exp Zool B Mol Dev Evol 312B(5):445-457
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