The active ingredient, khellin, is a class III antiarrhythmic agent that causes conversion to normal sinus rhythm by prolonging the duration of the myocardial action potential and refractory period through interaction with cellular potassium (K+) channeling.
Recommended dose rate is 16.0 mg/kg as a loading dose, followed by 5.0 - 9.0 mg/kg maintenance dose once daily.
- Pedro B et al (2012) Retrospective evaluation of the use of amiodarone in dogs with arrhythmias (from 2003 to 2010). J Small Anim Pract 53(1):19-26
- Souney PF (2009) Re: Adverse effects of intravenous amiodarone in 5 dogs. J Vet Intern Med 23(6):1127
- Saunders AB et al (2006) Oral amiodarone therapy in dogs with atrial fibrillation. J Vet Intern Med 20(4):921-926