Amlodipine

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Amlodipine is a long-acting calcium channel blocker used for the management of canine chronic renal disease.

This drug increases forward flow with afterload reduction because of the reduction in systemic vascular resistance[1], thereby allowing its use in the management of mitral valve endocardiosis, hypertrophic cardiomyopathy[2], atrial fibrillation[3] and systemic hypertension[4].

Recommended dose in dogs is 0.2 mg/kg twice daily per os[5].

References

  1. Strickland KN (2008) In: Manual of Canine and Feline Cardiology. 4. Tilley LP, Smith FWK Jr, Oyama MA, Sleeper MM, editor. Philadelphia: Saunders. Pathophysiology and Therapy of Heart Failure; pp:288–314
  2. Bright JM et al (1991) Evaluation of the calcium channel-blocking agents diltiazem and verapamil for treatment of feline hypertrophic cardiomyopathy. J Vet Intern Med 5(5):272–282
  3. Miyamoto M et al (2001) Acute cardiovascular effects of diltiazem in anesthetized dogs with induced atrial fibrillation. J Vet Intern Med 15(6):559–563
  4. Snyder PS et al (2001) Effect of amlodipine on echocardiographic variables in cats with systemic hypertension. J Vet Intern Med 15(1):52–56
  5. Suzuki S et al (2012) Long-term tolerability of benazepril in dogs with congestive heart failure. J Vet Cardiol 6(1):7-13