Amphotericin B

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Amphotericin B is an antimycotic drug used in severe fungal infections in dogs[1] that are non-responsive to terbinafine, or azole drugs such as itraconazole, fluconazole or ketoconazole.

Amphotericin B binds with ergosterol, a component of fungal cell membranes, forming a transmembrane channel that leads to ion leakage and fungal cell death.

This drug has also been used for treatment of Leishmania infantum infections[2].

Recommended dose rate is 0.5 mg/kg three times weekly, given as an intravenous or subcutaneous injection.

References

  1. López-Martínez R & Méndéz-Tovar LJ (2012) Blastomycosis. Clin Dermatol 30(6):565-572
  2. Aït-Oudhia K et al (2012) In vitro susceptibility to antimonials and amphotericin B of Leishmania infantum strains isolated from dogs in a region lacking drug selection pressure. Vet Parasitol 187(3-4):386-393