Amyloidosis is a relatively infrequent genetic or inflammatory disease of dogs.
Amyloid is produced due to aberrant misfolding of cellular protein, resulting in deposition of β-sheets of amyloid, a form of protein scar tissue. Depositions in cells is not normally pathogenic unless it interferes with normal organ function, and in dogs, these can occur in the heart, liver and kidney, resulting in failure of these organs.
Congenital renal amyloidosis is recognized in Shar-Pei dogs. Affected dogs usually present with weight loss, anorexia, icterus, lethargy, stranguria, and distal limb edema due to hypoproteinemia. In this breed, serum creatinine concentration was significantly and negatively associated with survival.
Cutaneous amyloidosis occurs as primary localized form or secondary to systemic amyloidosis. In dogs, cutaneous amyloidosis is usually associated secondarily with localized plasma cell proliferation or cutaneous extramedullary plasmacytoma, but primary cutaneous amyloidosis has been reported in the Golden Retreiver.
Renal amyloidosis is commonly seen with a number of infectious diseases, including:
Renal amyloidosis commonly results in nephrotic syndrome in severely affected dogs.
- Tufts University
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