From Dog

Atipamezole is a reversal agent used for obviating the sedative effects of medetomidine and xylazine.

Atipamezole is a potent and highly specific antagonist of centrally and peripherally located α2-adrenoceptors and has approximately 100 times more affinity than yohimbine at the α2D-adrenoceptors[1].

This drug also counteracts the clinical effects of amitraz toxicity more effectively than yohimbine[2].

Recommended dose for reversal is 50 - 300 μg/kg[3].


  1. Virtanen R (1989) Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet Scand Suppl 85:29–37
  2. Andrade SF &Sakate M (2003) The comparative efficacy of yohimbine and atipamezole to treat amitraz intoxication in dogs. Vet Hum Toxicol 45(3):124-127
  3. Ko JC et al (2013) Influence of ketamine on the cardiopulmonary effects of intramuscular administration of dexmedetomidine-buprenorphine with subsequent reversal with atipamezole in dogs. J Am Vet Med Assoc 242(3):339-345