Atovaquone

From Dog

Atovaquone (hydroxy-1,4-naphthoquinone) is a naphthoquinone analog.

This drug has poor water solubility and is usually incorporated into lipid-based formulations and requires to be given with a fatty meal for adequate absorption[1].

Atovaquone is indicated for use against canine infections caused by Toxoplasma spp, Babesia spp[2], Pneumocystis spp.

With Babesia spp infections, it is sometimes used in combination with azithromycin[3].

Recommended dose rate is 10 - 15 mg/kg with fatty meal given orally every 8 hours for 10 - 21 days.

References

  1. Sek L et al (2006) Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone. J Pharm Pharmacol 58(6):809-820
  2. Lin EC et al (2012) The therapeutic efficacy of two antibabesial strategies against Babesia gibsoni. Vet Parasitol 186(3-4):159-164
  3. Di Cicco MF et al (2012) Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin. Vet Parasitol 187(1-2):23-27