Azathioprine

From Dog

Azathioprine is an immunomodulatory chemotherapy drug which acts by inhibiting DNA synthesis, particularly on T cells and B cells.

It has been used in canine medicine for treatment of lymphoma, idiopathic aplastic pancytopenia[1], immune-mediated thrombocytopenia[2] and erythema multiforme.

The recommended dosage in dogs is 1 mg/kg, three times daily for 2 - 4 weeks or until a clinical response is seen.

References

  1. Kim JH et al (2012) Clinical and magnetic resonance imaging (MRI) findings of idiopathic aplastic pancytopenia in a dog treated with cyclosporine and azathioprine. Can Vet J 53(4):419-422
  2. Dircks B et al (2011) Clinical and laboratory-diagnosed parameters in 21 dogs with primary immune-mediated thrombocytopenia. Tierarztl Prax Ausg K Kleintiere Heimtiere 39(1) :17-24