Aztreonam

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Aztreonam.jpg

Aztreonam is a β-lactam antimicrobial similar in action of penicillin.

It has relative efficacy against Pseudomonas aeruginosa[1], Citrobacter spp, Enterobacter spp[2], E. coli[3], Haemophilus spp, Klebsiella spp, Proteus spp and Serratia spp.

Recommended dose rate in dogs is 12 - 25 mg/kg given intravenously or intramuscularly every 8 - 12 hours.

References

  1. Harada K et al (2012) Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms. Microbiol Immunol 56(2):123-127
  2. Sidjabat HE et al (2007) Identification of plasmid-mediated extended-spectrum and AmpC beta-lactamases in Enterobacter spp. isolated from dogs. J Med Microbiol 56(3):426-434
  3. Féria C et al (2002) Patterns and mechanisms of resistance to beta-lactams and beta-lactamase inhibitors in uropathogenic Escherichia coli isolated from dogs in Portugal. J Antimicrob Chemother 49(1):77-85