Bethanechol

From Dog

Bethanacol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors[1]. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action.

This drug, which causes a dose-dependent increase in bladder contraction[2], is commonly used in bladder disorders such as urinary retention[3], dysautonomia, incontinence and cystitis[4].

Recommended dose rate in dogs is 1.25 - 5.0 mg given orally every 8 - 12 hrs.

References

  1. Wikipedia.org
  2. Buranakarl C et al (2001) Effects of bethanechol on canine urinary bladder smooth muscle function. Res Vet Sci 71(3):175-181
  3. Kona-Boun JJ et al (2003) Myoclonus and urinary retention following subarachnoid morphine injection in a dog. Vet Anaesth Analg 30(4):257-264
  4. Biegen VR et al (2013) Successful treatment of encrusted cystitis associated with Staphylococcus pseudintermedius infection in the urinary bladder of a dog. J Am Vet Med Assoc 242(6):798-802