Bile acids

From Dog

Total serum bile acids are liver enzymes used for detection of various diseases in dogs such as cholangiohepatitis[1], portosystemic shunts, inflammatory bowel disease, pancreatitis and hyperadrenocorticism.

Measurements are usually performed before and 2 hr after meal ingestion with pre- and post-prandial ranges 0-10 and 0-20 μM/L respectively[2].

Insufficient hepatic processing of bile acids due to underlining diseases cause high bile acid levels and concentrations >25 μM/L should be considered abnormal either before or after a meal.

It should be noted that administration of glucocorticoids results in lower readings in dogs[3].

Liver biopsies are usually performed in suspicious cases.

References

  1. Osumi T et al (2011) A case of recovery from canine destructive cholangitis in a Miniature Dachshund. J Vet Med Sci 73(7):937-939
  2. Yoon H et al (2011) Contrast-enhanced computed tomography angiography and volume-rendered imaging for evaluation of cellophane banding in a dog with extrahepatic portosystemic shunt. J S Afr Vet Assoc 82(2):125-128
  3. Kook PH et al (2011) Effect of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs. Am J Vet Res 72(12):1607-1612